GRECCAR

Présentation

Le GRECCAR (GROUPE de RECHERCHE en CHIRURGIE DU RECTUM) est un groupe de recherche sur le cancer colo-rectal. Il a publié de nombreux essais randomisés ou études rétrospectives sur les modalités de prise en charge des cancers colo-rectaux.

Publications du GRECCAR

Liste mise à jour en octobre 2026 (source : PubMed). 57 publications.

2026

• Oncological impact of adjuvant chemotherapy after rectal cancer excision in the era of FOLFIRINOX-based TNT: A pooled post-hoc analysis of GRECCAR4-PRODIGE23.
  Denost Q, Rouanet P, Teruel E, Borg C, Lelong B, Etienne PL, Maingon P, Rio E, Tuech JJ, Noiret B, Nougaret S, Pezzela V, Gourgou S, Conroy T. Eur J Cancer. 2026;247:117046. doi:10.1016/j.ejca.2026.117046
• Organ Preservation in Rectal Cancer Management: A Prospective GRECCAR Snapshot Study.
  Noiret B, Manceau G, Fernandez B, Rouanet P, Buscail E, Trilling B, Meillat H, Lefèvre JH, Meurette G, Benoist S, Karoui M, Peru N, Maggiori L, Venara A, Ouaissi M, Djelil D, Germain A, Cotte E, Sabbagh C, Manfredelli S, Tuech JJ, Beyer-Berjot L, Alves A, Mege D, Marchal F, Fabre JM, Houlzé-Laroye C, Taoum C, Rivoire M, Denost Q. Dis Colon Rectum. 2026;69(7):1870-1879. doi:10.1097/DCR.0000000000004206
• Risk factors associated with urinary tract infection within 4 days of male rectal cancer surgery in the era of enhanced recovery after surgery (ERAS) programs.
  Faucheron JL, Tidadini F, Lakkis Z, Jafari M, Germain A, Rullier E, Lefevre J, Tuech JJ, Kartheuser A, Leonard D, Prudhomme M, Piessen G, Regimbeau JM, Cotte E, Duprez D, Badic B, Panis Y, Rivoire M, Meunier B, Portier G, Bosson JL, Vilotitch A, Foote A, Caspar Y, Rouanet P, Trilling B. Acta Chir Belg. 2026;126(5):188-194. doi:10.1080/00015458.2026.2682162
• Chemotherapy followed by pelvic reirradiation versus chemotherapy alone as preoperative treatment for locally recurrent rectal cancer (GRECCAR 15): superiority open-label phase III randomized clinical trial.
  Denost Q, Ghouti L, Tuech JJ, Rouanet P, Germain A, Rio E, Faucheron JL, Jafari M, Cotte E, Mineur L, De Chaisemartin C, Lefevre JH, Merdrignac A, Sitta R, Frison E, Vendrely V. Br J Surg. 2026. doi:10.1093/bjs/znag061
• Influence of Time Interval Between the 2 Stages of Delayed Coloanal Anastomosis on the Risk of Anastomotic Leakage: Multicenter Study From the GRECCAR Group.
  Collard MK, Fernandez B, Tuech JJ, Sabbagh C, Souadka A, Loriau J, Faucheron JL, Benoist S, Dubois A, Dumont F, Germain A, Manceau G, Marchal F, Benhaim L, Lakkis Z, Meillat H, Derieux S, Piessen G, Laforest A, Venara A, Prudhomme M, Brigand C, Duchalais E, Ouaissi M, Lebreton G, Rouanet P, Mège D, Pautrat K, Maggiori L, Reynolds IS, Pocard M, Parc Y, Denost Q, Lefevre JH. Dis Colon Rectum. 2026;69(2):235-244. doi:10.1097/DCR.0000000000004016
• A randomized phase III trial of structured tumour response surveillance and shared decision-making for organ preservation in rectal cancer – PRODIGE 101-GRECCAR 20-EVAREC trial protocol.
  Noiret B, Vendrely V, Delattre A, Vavasseur A, Maillou-Martinaud H, Nougaret S, Jacques J, Haaser T, Lepage C, Denost Q. Colorectal Dis. 2026;28(1):e70371. doi:10.1111/codi.70371
• Contemporary neoadjuvant strategies for rectal cancer: The GRECCAR snapshot study.
  Cazelles A, Denost Q, Fernandez B, Rivoire M, Meillat H, Rouanet P, Karoui M, Germain A, Maggiori L, Valverde A, Peru N, Cotte E, Buscail E, Lefevre JH, Trilling B, Faucheron JL, Sage PY, Beyer-Berjot L, Benoist S, Alves A, Sabbagh C, Tuech JJ, Coget J, Marchal F, Meurette G, Mège D, Djelil D, Manfredelli S, Venara A, Ouaissi M, Manceau G. Colorectal Dis. 2026;28(1):e70358. doi:10.1111/codi.70358

2025

• Delayed coloanal anastomosis for rectovaginal fistulas: Insights from a multicenter cohort (GRECCAR).
  Collard MK, Tuech JJ, Fernandez B, Benoist S, Faucheron JL, Sabbagh C, Loriau J, Benhaïm L, Protat A, Manceau G, Marchal F, Laforest A, Derieux S, Germain A, Manfredelli S, Pierre A, Mège D, Parc Y, Lefèvre JH. Surgery. 2025;188:109767. doi:10.1016/j.surg.2025.109767
• Outpatient Stoma Closure in 130 Patients: Insights From the GRECCAR Multicentric Study.
  Cleret de Langavant B, Camerlo A, Denost Q, Beyer-Berjot L, Collard MK, Parc Y, Gignoux B, Lefevre JH. Ann Surg. 2025;282(5):845-851. doi:10.1097/SLA.0000000000006875
• Management of Low Colorectal/Coloanal Anastomotic Leak: Results of a French National Intergroups Practice Survey (FRENCH-GRECCAR-SFCD).
  Pastier C, Ben Hmida W, Lefèvre JH, Denost Q, Schwarz L, Berdah S, Cotte E, Karoui M, Maggiori L, Abdalla S, Brouquet A, Benoist S. World J Surg. 2025;49(7):1747-1756. doi:10.1002/wjs.12634
• Risk of distant metastasis after local excision for near-complete response versus salvage surgery for local regrowth in rectal cancer: Results from an international registry.
  Jehaes C, Panis Y, Fernandez L, Lelong B, Julião GS, Vailati B, Lefevre JH, Tuech JJ, Azevedo J, Benoist S, Parvaiz A, Mege D, Habr-Gama A, Perez R, Denost Q. Eur J Surg Oncol. 2025;51(7):109761. doi:10.1016/j.ejso.2025.109761
• Intraoperative indocyanine green fluorescence angiography in colorectal surgery to prevent anastomotic leakage: A single-blind phase III multicentre randomized controlled trial (FLUOCOL-01/FRENCH 21/GRECCAR 19 intergroup trial).
  Pretalli JB, Vernerey D, Evrard P, Pozet A, Clairet AL, Benoist S, Karoui M, Cotte E, Heyd B, Lakkis Z. Colorectal Dis. 2025;27(5):e70119. doi:10.1111/codi.70119
• Urinary retention after laparoscopic low rectal cancer resection: post-hoc analysis of predictive factors in the GRECCAR 10 trial.
  Faucheron JL, Tidadini F, Vilotitch A, Foote A, Trilling B. Br J Surg. 2025;112(3):znae315. doi:10.1093/bjs/znae315
• Rectal cancer – French intergroup clinical practice guidelines for diagnosis, treatment, and follow-up (TNCD, SNFGE, FFCD, GERCOR, UNICANCER, SFCD, SFED, SFRO, ACHBT, SFP, RENAPE, SNFCP, AFEF, SFR, and GRECCAR).
  Cotte E, Arquilliere J, Artru P, Bachet JB, Benhaim L, Bibeau F, Christou N, Conroy T, Doyen J, Hoeffel C, Meillan N, Mirabel X, Pioche M, Rivin Del Campo E, Vendrely V, Huguet F, Bouché O. Dig Liver Dis. 2025;57(3):669-679. doi:10.1016/j.dld.2024.12.004
• Long-term bowel function following delayed coloanal anastomosis: Analysis of a multicentric cohort study (GRECCAR).
  Collard MK, Tuech JJ, Sabbagh C, Souadka A, Loriau J, Rullier E, Marchal F, Germain A, Benoist S, Faucheron JL, Manceau G, Dubois A, Laforest A, Sourrouille I, Protat A, Mège D, Lakkis Z, Prudhomme M, Derieux S, Ouaissi M, Venara A, Brigand C, Lelong B, Pautrat K, Maggiori L, Lebreton G, Rouanet P, Pocard M, Duchalais E, Denost Q, Parc Y, Lefevre JH. Colorectal Dis. 2025;27(2):e70013. doi:10.1111/codi.70013
• Final Results of the GRECCAR-6 Trial on Waiting Period Following Neoadjuvant Radiochemotherapy for Locally Advanced Rectal Cancer: 5 Years of Follow-up.
  Collard MK, Mineur L, Nekrouf C, Denost Q, Rouanet P, de Chaisemartin C, Merdrignac A, Jafari M, Cotte E, Desrame J, Manceau G, Benoist S, Buscail E, Karoui M, Panis Y, Piessen G, Saudemont A, Prudhomme M, Peschaud F, Dubois A, Loriau J, Tuech JJ, Duchalais E, Lupinacci RM, Goasguen N, Simon T, Parc Y, Lefevre JH. Dis Colon Rectum. 2025;68(2):199-208. doi:10.1097/DCR.0000000000003477

2024

• Effect of Sublay Preventive Mesh for Terminal Colostomy on Symptoms and Quality of Life in Patients With Parastomal Hernia: A Post Hoc Analysis of the GRECCAR 7 Cohort.
  Bertrand MM, Theuil L, Demattei C, Prudhomme M. Dis Colon Rectum. 2024;67(9):1210-1216. doi:10.1097/DCR.0000000000003257
• Suprapubic versus transurethral catheterization for bladder drainage in male rectal cancer surgery (GRECCAR10), a randomized clinical trial.
  Trilling B, Tidadini F, Lakkis Z, Jafari M, Germain A, Rullier E, Lefevre J, Tuech JJ, Kartheuser A, Leonard D, Prudhomme M, Piessen G, Regimbeau JM, Cotte E, Duprez D, Badic B, Panis Y, Rivoire M, Meunier B, Portier G, Bosson JL, Vilotitch A, Foote A, Caspar Y, Rouanet P, Faucheron JL. Tech Coloproctol. 2024;28(1):77. doi:10.1007/s10151-024-02950-2

2023

• Is Delaying a Coloanal Anastomosis the Ideal Solution for Rectal Surgery?: Analysis of a Multicentric Cohort of 564 Patients From the GRECCAR.
  Collard MK, Rullier E, Tuech JJ, Sabbagh C, Souadka A, Loriau J, Faucheron JL, Benoist S, Dubois A, Dumont F, Germain A, Manceau G, Marchal F, Sourrouille I, Lakkis Z, Lelong B, Derieux S, Piessen G, Laforest A, Venara A, Prudhomme M, Brigand C, Duchalais E, Ouaissi M, Lebreton G, Rouanet P, Mège D, Pautrat K, Reynolds IS, Pocard M, Parc Y, Denost Q, Lefevre JH. Ann Surg. 2023;278(5):781-789. doi:10.1097/SLA.0000000000006025
• GRECCAR 14 – a multicentric, randomized, phase II-III study evaluating the tailored management of locally advanced rectal carcinoma after a favourable response to induction chemotherapy: Study protocol.
  Rouanet P, Castan F, Mazard T, Lemanski C, Nougaret S, Deshayes E, Chalbos P, Gourgou S, Taoum C. Colorectal Dis. 2023;25(10):2078-2086. doi:10.1111/codi.16740
• Local excision after neoadjuvant chemoradiotherapy for mid and low rectal cancer: a multicentric French study from the GRECCAR group.
  Calmels M, Labiad C, Lelong B, Lefevre JH, Tuech JJ, Benoist S, Mège D, Denost Q, Panis Y. Colorectal Dis. 2023;25(10):1973-1980. doi:10.1111/codi.16742
• Iatrogenic ureteral injury during colorectal surgery has a significant impact on patient outcomes: a French multicentric retrospective cohort study.
  Sérénon V, Rouanet P, Charleux-Muller D, Eveno C, Poirot K, Trilling B, Benoist S, Manceau G, Panis Y, Alves A, Kartheuser A, Venara A, Pocard M, Sabbagh C, Laforest A, Lakkis Z, Badic B, Chau A, Christou N, Beyer-Berjot L, Dumont F, Germain A, Valverde A, Duchalais E, Ouaissi M, Benhaim L, Collard M, Tuech JJ, Buscail E, Mege D. Colorectal Dis. 2023;25(7):1433-1445. doi:10.1111/codi.16630
• MRI restaging of rectal cancer: The RAC (Response-Anal canal-CRM) analysis joint consensus guidelines of the GRERCAR and GRECCAR groups.
  Nougaret S, Rousset P, Lambregts DMJ, Maas M, Gormly K, Lucidarme O, Brunelle S, Milot L, Arrivé L, Salut C, Pilleul F, Hordonneau C, Baudin G, Soyer P, Brun V, Laurent V, Savoye-Collet C, Petkovska I, Gerard JP, Cotte E, Rouanet P, Catalano O, Denost Q, Beets-Tan RGH, Frulio N, Hoeffel C. Diagn Interv Imaging. 2023;104(7-8):311-322. doi:10.1016/j.diii.2023.02.002
• A phase III randomized trial evaluating the quality of life impact of a tailored versus systematic use of defunctioning ileostomy following total mesorectal excision for rectal cancer-GRECCAR 17 trial protocol.
  Denost Q, Sylla D, Fleming C, Maillou-Martinaud H, Preaubert-Hayes N, Benard A. Colorectal Dis. 2023;25(3):443-452. doi:10.1111/codi.16428

2022

• Tailored Strategy for Locally Advanced Rectal Carcinoma (GRECCAR 4): Long-term Results From a Multicenter, Randomized, Open-Label, Phase II Trial.
  Rouanet P, Rullier E, Lelong B, Maingon P, Tuech JJ, Pezet D, Castan F, Nougaret S. Dis Colon Rectum. 2022;65(8):986-995. doi:10.1097/DCR.0000000000002153
• Nonmetastatic ypT0 rectal cancer after neoadjuvant treatment and total mesorectal excision: Lessons from a retrospective multicentric cohort of 383 patients.
  Collard MK, Rullier E, Panis Y, Manceau G, Benoist S, Tuech JJ, Alves A, Laforest A, Mege D, Cazelles A, Beyer-Berjot L, Christou N, Cotte E, Lakkis Z, O’Connell L, Parc Y, Piessen G, Lefevre JH. Surgery. 2022;171(5):1193-1199. doi:10.1016/j.surg.2021.10.003
• Is it safe to perform an anastomosis for rectal cancer after prostate cancer? A multicentre study of 126 patients from the GRECCAR group.
  Lakkis Z, Doussot A, Manfredelli S, Vernerey D, Meillat H, Ouaissi M, Cotte E, Faucheron JL, Piessen G, Tuech JJ, Lefevre JH, Panis Y, Beyer L, Brouquet A, Dumont F, Meurisse A, Rullier E, Heyd B. Colorectal Dis. 2022;24(5):594-600. doi:10.1111/codi.16054
• Structured and shared MRI staging lexicon and report of rectal cancer: A consensus proposal by the French Radiology Group (GRERCAR) and Surgical Group (GRECCAR) for rectal cancer.
  Nougaret S, Rousset P, Gormly K, Lucidarme O, Brunelle S, Milot L, Salut C, Pilleul F, Arrivé L, Hordonneau C, Baudin G, Soyer P, Brun V, Laurent V, Savoye-Collet C, Petkovska I, Gerard JP, Rullier E, Cotte E, Rouanet P, Beets-Tan RGH, Frulio N, Hoeffel C. Diagn Interv Imaging. 2022;103(3):127-141. doi:10.1016/j.diii.2021.08.003
• What Is the Optimal Elective Colectomy for Splenic Flexure Cancer: End of the Debate? A Multicenter Study From the GRECCAR Group With a Propensity Score Analysis.
  Manceau G, Alves A, Meillat H, Benhaïm L, Ouaïssi M, Panis YH, Tuech JJ, Dousset B, Brigand C, Cotte E, Lakkis Z, Badic B, Marchal F, Sabbagh C, Diouf M, Karoui M. Dis Colon Rectum. 2022;65(1):55-65. doi:10.1097/DCR.0000000000001937

2021

• End Colostomy With or Without Mesh to Prevent a Parastomal Hernia (GRECCAR 7): A Prospective, Randomized, Double Blinded, Multicentre Trial.
  Prudhomme M, Rullier E, Lakkis Z, Cotte E, Panis Y, Meunier B, Rouanet P, Tuech JJ, Jafari M, Portier G, Dubois A, Sielezneff I, Parc Y, Faucheron JL, Meurette G, Lelong B, Piessen G, Karoui M, Fabbro-Peray P, Demattei C, Bertrand MM. Ann Surg. 2021;274(6):928-934. doi:10.1097/SLA.0000000000004371
• Surgical Management of Retrorectal Tumors: A French Multicentric Experience of 270 Consecutives Cases.
  Aubert M, Mege D, Parc Y, Rullier E, Cotte E, Meurette G, Zerbib P, Trilling B, Lelong B, Sabbagh C, Lakkis Z, Ouaissi M, Lebreton G, Rouanet P, Manceau G, Tuech JJ, Piessen G, Bresler L, Beyer-Berjot L, Denost Q, Lefèvre JH, Panis Y. Ann Surg. 2021;274(5):766-772. doi:10.1097/SLA.0000000000005119
• Radiomics modelling in rectal cancer to predict disease-free survival: evaluation of different approaches.
  Tibermacine H, Rouanet P, Sbarra M, Forghani R, Reinhold C, Nougaret S. Br J Surg. 2021;108(10):1243-1250. doi:10.1093/bjs/znab191
• A phase III randomized trial evaluating chemotherapy followed by pelvic reirradiation versus chemotherapy alone as preoperative treatment for locally recurrent rectal cancer – GRECCAR 15 trial protocol.
  Denost Q, Frison E, Salut C, Sitta R, Rullier A, Harji D, Maillou-Martinaud H, Rullier E, Smith D, Vendrely V. Colorectal Dis. 2021;23(7):1909-1918. doi:10.1111/codi.15670
• Impact of early biochemical diagnosis of anastomotic leakage after rectal cancer surgery: long-term results from GRECCAR 5 trial.
  Denost Q, Rouanet P, Faucheron JL, Panis Y, Meunier B, Cotte E, Meurette G, Portier G, Sabbagh C, Loriau J, Benoist S, Piessen G, Sielezneff I, Lelong B, Mauvais F, Romain B, Barussaud ML, Capdepont M, Laurent C, Rullier E. Br J Surg. 2021;108(6):605-608. doi:10.1093/bjs/znab003
• Randomised clinical trial for the cost-utility evaluation of two strategies of perineal reconstruction after abdominoperineal resection in the context of anorectal carcinoma: biological mesh repair versus primary perineal wound closure, study protocol for the GRECCAR 9 Study.
  Buscail E, Canivet C, Ghouti L, Kirzin S, Carrere N, Molinier L, Rosillo A, Lauwers-Cances V, Costa N. BMJ Open. 2021;11(4):e043333. doi:10.1136/bmjopen-2020-043333
• Are colorectal cancer patients at risk for COVID-19 infection during the postoperative period? The Covid-GRECCAR study.
  Tuech JJ, Manceau G, Ouaissi M, Denet C, Chau A, Kartheuser A, Desfourneaux V, Duchalais E, Bertrand M, Badic B, Alves A, Ceribelli C, Venara A, Mege D, Mauvais F, Dumont F, Mabrut JY, Lakkis Z, Cotte E, Meillat H. Int J Colorectal Dis. 2021;36(3):611-615. doi:10.1007/s00384-021-03847-4
• Sphincter-saving surgery after neoadjuvant therapy for ultra-low rectal cancer where abdominoperineal resection was indicated: 10-year results of the GRECCAR 1 trial.
  Rouanet P, Rivoire M, Gourgou S, Lelong B, Rullier E, Jafari M, Mineur L, Pocard M, Faucheron JL, Dravet F, Pezet D, Fabre JM, Bresler L, Balosso J, Lemanski C. Br J Surg. 2021;108(1):10-13. doi:10.1093/bjs/znaa010
• Sphincter-saving surgery for ultra-low rectal carcinoma initially indicated for abdominoperineal resection: Is it safe on a long-term follow-up?
  Rouanet P, Rivoire M, Gourgou S, Lelong B, Rullier E, Jafari M, Mineur L, Pocard M, Faucheron JL, Dravet F, Pezet D, Fabre JM, Bresler L, Balosso J, Taoum C, Lemanski C. J Surg Oncol. 2021;123(1):299-310. doi:10.1002/jso.26249

2020

• Surgical Management and Outcomes of Rectal Cancer with Synchronous Prostate Cancer: A Multicenter Experience from the GRECCAR Group.
  Doussot A, Vernerey D, Rullier E, Lefevre JH, Meillat H, Cotte E, Piessen G, Tuech JJ, Panis Y, Mege D, Meurisse A, De Bari B, Heyd B, Lakkis Z. Ann Surg Oncol. 2020;27(11):4286-4293. doi:10.1245/s10434-020-08683-4
• NORAD01-GRECCAR16 multicenter phase III non-inferiority randomized trial comparing preoperative modified FOLFIRINOX without irradiation to radiochemotherapy for resectable locally advanced rectal cancer (intergroup FRENCH-GRECCAR-PRODIGE trial).
  Brouquet A, Bachet JB, Huguet F, Karoui M, Artru P, Sabbagh C, Lefèvre JH, Vernerey D, Mariette C, Vicaut E, Benoist S. BMC Cancer. 2020;20(1):485. doi:10.1186/s12885-020-06968-1
• Organ preservation with chemoradiotherapy plus local excision for rectal cancer: 5-year results of the GRECCAR 2 randomised trial.
  Rullier E, Vendrely V, Asselineau J, Rouanet P, Tuech JJ, Valverde A, de Chaisemartin C, Rivoire M, Trilling B, Jafari M, Portier G, Meunier B, Sieleznieff I, Bertrand M, Marchal F, Dubois A, Pocard M, Rullier A, Smith D, Frulio N, Frison E, Denost Q. Lancet Gastroenterol Hepatol. 2020;5(5):465-474. doi:10.1016/S2468-1253(19)30410-8
• Short-term and Long-term Outcome of Endoluminal Vacuum Therapy for Colorectal or Coloanal Anastomotic Leakage: Results of a Nationwide Multicenter Cohort Study From the French GRECCAR Group.
  Abdalla S, Cotte E, Epin A, Karoui M, Lefevre JH, Berger A, Marchal F, Denost Q, Penna C, Benoist S, Brouquet A. Dis Colon Rectum. 2020;63(3):371-380. doi:10.1097/DCR.0000000000001560
• Elective surgery for tumours of the splenic flexure: a French inter-group (AFC, SFCD, FRENCH, GRECCAR) survey.
  Manceau G, Benoist S, Panis Y, Rault A, Mathonnet M, Goere D, Tuech JJ, Collet D, Penna C, Karoui M. Tech Coloproctol. 2020;24(2):191-198. doi:10.1007/s10151-019-02143-2

2019

• Does A Longer Waiting Period After Neoadjuvant Radio-chemotherapy Improve the Oncological Prognosis of Rectal Cancer?: Three Years’ Follow-up Results of the Greccar-6 Randomized Multicenter Trial.
  Lefèvre JH, Mineur L, Cachanado M, Denost Q, Rouanet P, de Chaisemartin C, Meunier B, Mehrdad J, Cotte E, Desrame J, Karoui M, Benoist S, Kirzin S, Berger A, Panis Y, Piessen G, Saudemont A, Prudhomme M, Peschaud F, Dubois A, Loriau J, Tuech JJ, Meurette G, Lupinacci R, Goasguen N, Creavin B, Simon T, Parc Y. Ann Surg. 2019;270(5):747-754. doi:10.1097/SLA.0000000000003530
• Early MRI predictors of disease-free survival in locally advanced rectal cancer from the GRECCAR 4 trial.
  Nougaret S, Castan F, de Forges H, Vargas HA, Gallix B, Gourgou S, Rouanet P. Br J Surg. 2019;106(11):1530-1541. doi:10.1002/bjs.11233
• Morbidity and oncological outcomes of rectal cancer impaired by previous prostate malignancy.
  Lakkis Z, Vernerey D, Mege D, Faucheron JL, Panis Y, Tuech JJ, Lefevre JH, Brouquet A, Dumont F, Borg C, Woronoff AS, Meurisse A, Heyd B, Rullier E. Br J Surg. 2019;106(8):1087-1098. doi:10.1002/bjs.11176

2017

• Organ preservation for rectal cancer (GRECCAR 2): a prospective, randomised, open-label, multicentre, phase 3 trial.
  Rullier E, Rouanet P, Tuech JJ, Valverde A, Lelong B, Rivoire M, Faucheron JL, Jafari M, Portier G, Meunier B, Sileznieff I, Prudhomme M, Marchal F, Pocard M, Pezet D, Rullier A, Vendrely V, Denost Q, Asselineau J, Doussau A. Lancet. 2017;390(10093):469-479. doi:10.1016/S0140-6736(17)31056-5
• Tailored Treatment Strategy for Locally Advanced Rectal Carcinoma Based on the Tumor Response to Induction Chemotherapy: Preliminary Results of the French Phase II Multicenter GRECCAR4 Trial.
  Rouanet P, Rullier E, Lelong B, Maingon P, Tuech JJ, Pezet D, Castan F, Nougaret S. Dis Colon Rectum. 2017;60(7):653-663. doi:10.1097/DCR.0000000000000849
• A multicentre randomised controlled trial to evaluate the efficacy, morbidity and functional outcome of endoscopic transanal proctectomy versus laparoscopic proctectomy for low-lying rectal cancer (ETAP-GRECCAR 11 TRIAL): rationale and design.
  Lelong B, de Chaisemartin C, Meillat H, Cournier S, Boher JM, Genre D, Karoui M, Tuech JJ, Delpero JR. BMC Cancer. 2017;17(1):253. doi:10.1186/s12885-017-3200-1
• To Drain or Not to Drain Infraperitoneal Anastomosis After Rectal Excision for Cancer: The GRECCAR 5 Randomized Trial.
  Denost Q, Rouanet P, Faucheron JL, Panis Y, Meunier B, Cotte E, Meurette G, Kirzin S, Sabbagh C, Loriau J, Benoist S, Mariette C, Sielezneff I, Lelong B, Mauvais F, Romain B, Barussaud ML, Germain C, Picat MQ, Rullier E, Laurent C. Ann Surg. 2017;265(3):474-480. doi:10.1097/SLA.0000000000001991
• Management of rectal cancer: the 2016 French guidelines.
  Lakkis Z, Manceau G, Bridoux V, Brouquet A, Kirzin S, Maggiori L, de Chaisemartin C, Lefevre JH, Panis Y. Colorectal Dis. 2017;19(2):115-122. doi:10.1111/codi.13550

2016

• Effect of Interval (7 or 11 weeks) Between Neoadjuvant Radiochemotherapy and Surgery on Complete Pathologic Response in Rectal Cancer: A Multicenter, Randomized, Controlled Trial (GRECCAR-6).
  Lefevre JH, Mineur L, Kotti S, Rullier E, Rouanet P, de Chaisemartin C, Meunier B, Mehrdad J, Cotte E, Desrame J, Karoui M, Benoist S, Kirzin S, Berger A, Panis Y, Piessen G, Saudemont A, Prudhomme M, Peschaud F, Dubois A, Loriau J, Tuech JJ, Meurette G, Lupinacci R, Goasgen N, Parc Y, Simon T, Tiret E. J Clin Oncol. 2016;34(31):3773-3780. doi:10.1200/JCO.2016.67.6049
• Primary prevention of peristomial hernias via parietal prostheses: A randomized, multicentric study (GRECCAR 7 trial).
  Prudhomme M, Alline M, Chauvat J, Fabbro-Perray P, Ripoche J, Bertrand MM. Dig Liver Dis. 2016;48(7):812-816. doi:10.1016/j.dld.2016.03.020

2015

• Increasing the Interval Between Neoadjuvant Chemoradiotherapy and Surgery in Rectal Cancer.
  Lefevre JH, Parc Y, Tiret E. Ann Surg. 2015;262(6):e116. doi:10.1097/SLA.0000000000000771
• GRECCAR 8: impact on survival of the primary tumor resection in rectal cancer with unresectable synchronous metastasis: a randomized multicentre study.
  Cotte E, Villeneuve L, Passot G, Boschetti G, Bin-Dorel S, Francois Y, Glehen O. BMC Cancer. 2015;15:47. doi:10.1186/s12885-015-1060-0

2013

• A multicentric randomized controlled trial on the impact of lengthening the interval between neoadjuvant radiochemotherapy and surgery on complete pathological response in rectal cancer (GRECCAR-6 trial): rationale and design.
  Lefevre JH, Rousseau A, Svrcek M, Parc Y, Simon T, Tiret E. BMC Cancer. 2013;13:417. doi:10.1186/1471-2407-13-417

2010

Rectal cancer surgery with or without bowel preparation: The French GRECCAR III multicenter single-blinded randomized trial.
Bretagnol F, Panis Y, Rullier E, Rouanet P, Berdah S, Dousset B, Portier G, Benoist S, Chipponi J, Vicaut E. Ann Surg. 2010;252(5):863-868. doi:10.1097/SLA.0b013e3181fd8ea9